Abstract: Objective To optimize the invasive blood pressure monitoring arterial cannulation procedure using catheter tip intracavitary electrocardiogram （ECG） positioning technology and to evaluate its effectiveness. Methods From June 2021 to June 2022，60 patients each from a tertiary level A hospital and a secondary level A hospital in Xinjiang Uygur Autonomous Region undergoing invasive blood pressure monitoring were selected. Based on the cannulation method，they were randomly divided into the optimization group（60 patients） and the traditional group（60 patients） by the random number table method. The optimization group optimized the connection process be- tween arterial puncture cannula and pressure transducer，and introduced intracavitary electrogram localization tech- nology at the tip of arterial puncture. The traditional group used penetrating arterial puncture catheterization. The primary evaluation indicators included first-attempt cannulation success rate，post-puncture bruising，puncture bleed- ing，pain score，and patient satisfaction. Results Compared to the traditional group，the first-attempt cannulation suc- cess rate in the optimization group significantly increased（95.0% vs 83.3%，P=0.04）. The post-puncture bruising rate significantly decreased（5.0% vs 28.3%，P=0.01）. The puncture bleeding rate significantly decreased（0 vs 100.0%，P= 0.04）. The proportion of patients with mild pain significantly increased（95.0% vs 75.0%，P=0.02），while the propor- tion with moderate pain significantly decreased （5.0% vs 25.0%，P=0.02）. Patient satisfaction also improved（95.0% vs 75.0%，P=0.01）. Conclusion Optimizing the procedure of arterial cannulation for invasive blood pressure moni- toring can effectively improve the first-attempt puncture success rate，reduce complications，and enhance patient sat- isfaction. It offers a safer and more efficient cannulation method.

Key words: Invasive Blood Pressure Monitoring, Arterial Puncture Catheterization, Electrographic Positioning Technology, Process Optimization, Effect Evaluation