Abstract: Objective To analyze the characteristics and nursing strategies of adverse reactions of acetylcysteine in emergency infusion patients,in order to provide reference for clinical safe medication. Methods 26 patients who had adverse drug reactions of acetylcysteine during emergency infusion were selected from November 2019 to August 2022 in a tertiary hospital in Nanjing. The analysis was performed on indication,dosages,type and amount of solvent,drip speed of acetylcysteine injection and time of adverse reactions,clinical manifestation,severity,outcome,influence on original diseases and relation evaluation. Results All of the adverse drug reactions were general adverse reactions,and had no obvious influence on their original diseases. The average time from acetylcysteine intravenous infusion to the occurrence of observed adverse drug reactions was 99.7 minutes,and drip speed ranged from 10 to 69 droplets per minute. The manifestations of adverse drug reactions were common in skin and digestive system symptoms. In relevance evaluation,“probable” and “definite” cases accounted for 88.5% of all adverse drug reactions cases. Conclusion Acetylcysteine should be strictly administrated in emergency infusion patients according to instructions. And its drip speed should be strictly controlled during the treatment. The clinical manifestation during the first 2 hours after the administration of drugs should be closely monitored.

Key words: Acetylcysteine, Adverse Drug Reaction, Emergency Nursing, Transfusion