总结1例系统性红斑狼疮患儿开展嵌合抗原受体T细胞免疫疗法（chimeric antigen receptor T-cells，CAR-T）的护理体会。护理要点：输注前成立多学科团队，制订个性化评估表，落实高风险防范措施；精准回输CAR-T细胞，严密监护；输注后加强对细胞因子释放综合征和免疫效应细胞相关神经毒性综合征等不良反应的管理，使患儿顺利度过危险期；同时，关注患儿心理，做好趣味性叙事护理。通过个体化治疗和护理，患儿病情得到有效控制，顺利出院；回输后3个月，系统性红斑狼疮病情活动指数降至0，24 h尿蛋白降至62.5 mg。

To summarize the nursing experience of chimeric antigen receptor T-cell（CAR-T） immunotherapy in a child with systemic lupus erythematosus. The key nursing points included：setting up a multidisciplinary team before infusion to develop a personalized assessment scale and implement high risk prevention，precise reinfusion of CAR T-cells and close monitoring，strengthening the management of adverse reactions such as cytokine release syndrome and immune effector cell-related neurotoxic syndrome after infusion. At the same time，the team paied attention to children’s psychology and did fun narrative nursing. Through individualized treatment and nursing，the child’s condition was effectively controlled and discharged smoothly. Three months after transfusion，the disease activity index of systemic lupus erythematosus decreased to 0，and the 24-hour urine protein decreased to 62.5 mg.