总结1例烟曲霉菌感染致重度急性呼吸窘迫综合征患者行静脉-静脉体外膜肺氧合俯卧位治疗的护理体会。护理要点：针对患者严重的肺部感染，俯卧位体外膜肺氧合的转运风险及抗凝管理和多重耐药菌感染等问题，采取个性化俯卧位与精准引流策略，优化肺部感染控制；安全精细管道管理策略，保障体外膜氧合俯卧位转运安全；目标导向抗凝管理，平衡出血与血栓风险；多途径联合抗菌策略，增强疗效并减少副作用。经过57 d的治疗及护理，患者病情稳定顺利出院。

To summarize the nursing experience of a patient with severe acute respiratory distress syndrome caused by Aspergillus fumigatus infection undergoing veno-venous extracorporeal membrane oxygenation in prone position treatment. In response to severe pulmonary infections，the transportation risks during prone ECMO，anticoagulant management，as well as the multiple drug resistant bacterial infections in the patient，we adopted personalized prone position and precise drainage strategy to optimize lung infection control，safe and precise pipeline management strategy to ensure the safe transport of ECMO in prone position，goal oriented anticoagulation management to balance the risks of bleeding and thrombosis，multiple pathway combined antibacterial strategy to enhance efficacy of treatment and reduce side effects. After 57 days of treatment and nursing，the patient’s condition was stabilized and discharged smoothly.