总结3例神经母细胞瘤扩增序列基因突变致儿童急性肝功能衰竭的护理体会。 针对本组患儿高氨血症引发肝性脑病、感染引起高热、分解代谢增加及出院后护理等问题，采取严密监测意识评估肝性脑病发展，及时采取合适的血液净化方式快速降血氨；预防与控制感染，尤其是体温管理；加强营养支持；定期跟踪随访，避免再次发生急 性肝功能衰竭。 经过快速救治及精心护理，3例患儿病情稳定出院，出院后3个月随访恢复良好。

To summarize the nursing experience of 3 children with acute liver failure caused by neuroblastoma amplified sequence gene mutations. In view of the problems of hepatic encephalopathy caused by hyperammonemia， high fever and increased catabolism caused by infection，and post-discharge care in this group of children，we adopted strict monitoring of awareness to evaluate the development of hepatic encephalopathy，and appropriate blood purification methods in a timely manner to quickly lower blood ammonia；prevention and control of infection， especially body temperature management；strengthening nutritional support；regular follow-up to avoid recurrence of acute liver failure. After rapid treatment and careful care，the three children were discharged from the hospital in stable condition and recovered well during 3 months of follow-up after discharge.