总结1例Lemierre综合征患者机械通气撤机后继发声门闭合不全的护理体会。针对患者撤机难度大，再插管风险高等问题，采取急性期呼吸支持；拔管前风险评估、多学科制订拔管策略、拔管后观察与应急处置；预警评估，平衡出血与血栓，积极控制感染，预防交叉感染；阶段性康复训练，目标导向营养支持及正性心理支持等措施。经过25 d积极治疗与护理， 患者病情好转，转康复医院继续治疗。 随访3个月，患者生活恢复正常。

To summarize the nursing experience of weaning in a ventilated patient with Lemierre syndrome and secondary glottis imperfection. In view of the difficulty of weaning and the high risk of re- intubation，we adopted respiratory support in acute phase，risk assessment before extubation and multi-disciplinary extubation strategy，post-extubation observation and emergency treatment，early warning assessment to balance bleeding and thrombosis，active infection control to prevent cross infection，staged rehabilitation training，goal-oriented nutritional support and positive psychological support and other measures. After 25 days of active treatment and nursing，the patient’s condition improved，transferred to the rehabilitation hospital for continue treatment. The patients were followed up for 3 months and his life returned to normal.