总结1例抗N-甲基-D-天冬氨酸受体脑炎伴中毒性表皮坏死松解症患儿的护理体会。护理要点院早期识别药疹进展及病情变化，全程监护可疑致敏药物，按照皮损演变过程和疾病特点提供个体化皮肤黏膜护理，精准控制创面感染，落实程序性疼痛策略，做好黏膜屏障受损状态下的静脉通路维护及液体管理，积极开展儿童医疗辅助服务， 消除其负性情绪等。 经过56 d的治疗和护理，患儿病情好转出院，现恢复良好。

To summarize the nursing experience of a child with anti N-methyl-D-aspartate receptor encephalitis with toxic epidermal necrolysis. Early identification of condition changes，full monitoring of suspected allergenic drugs，personalized skin and mucosal care based on the evolution process of the skin lesion and the characteristics of the disease，precise control of wound infection，implementation of procedural pain strategies，maintenance of venous pathways and fluid management under the condition of mucosal barrier damage，active provision of children’s medical assistance services，and elimination of negative emotions were taken. After 56 days of treatment and care， the child’s condition improved and was discharged from the hospital. He is now recovering well.