收稿日期: 2024-12-16
网络出版日期: 2025-11-04
基金资助
浙江省医药卫生科技计划项目(2024KY084);浙江省医药卫生科技计划项目(2025KY070)
Study on the longitudinal change trajectory and influencing factors of symptoms in patients undergoing daytime lung cancer surgery after discharge
Received date: 2024-12-16
Online published: 2025-11-04
目的 探讨日间肺癌手术患者出院后症状的动态变化,并分析其影响因素。 方法 采用纵向研究设计,采用便利抽样法选取浙江省某三级甲等医院2023年10月—2024年1月的日间肺癌手术患者,通过肺癌患者术后症状量表评估其出院第1、3、14、30天的症状。使用组轨迹模型(Group-Based Trajectory Modeling,GBTM)识别患者的出院后症状轨迹类别,分析不同轨迹组的患者特征差异,并使用人均症状指数分析单个术后反应症状的纵向变化。结果 共纳入206例患者,识别出3个轨迹组:轻微症状—缓慢减轻组(n=184,89.32%)、严重症状—快速减轻组(n=19,9.22%)、轻微症状—加重组(n=3,1.46%)。年龄、手术方式、病理类型在不同出院后症状轨迹组中存在差异(P<0.05)。在出院第1天咳嗽和疼痛是最常见症状,分别为180例(87.38%)和197例(95.63%),出院第30天咳嗽仍是主要症状(n=129,62.62%)。人均症状反应指数中,便秘由第1天的7.9上升至第3天的9.2,气促从第1天的2.7到第14天增至6.7。结论 日间肺癌患者出院后的症状动态变化存在异质性,医护人员可根据不同轨迹组患者特征差异及单一症状的人均症状反应指数变化,制订针对性的护理策略,提升患者康复进度,从而提供高质量的全病程护理服务。
韩娜菲 , 安传波 , 袁华娣 , 兰美娟 , 贺红 , 吴小燕 , 柳利 , 高丽燕 , 辛鼎杰 , 徐小林 . 日间肺癌手术患者出院后症状纵向变化轨迹及影响因素研究[J]. 中华急危重症护理杂志, 2025 , 6(11) : 1335 -1341 . DOI: 10.3761/j.issn.2096-7446.2025.11.009
Objective To explore the dynamic changes of symptoms after discharge among patients undergoing daytime lung cancer surgery and analyze their influencing factors. Methods A longitudinal study was conducted in a tertiary hospital in Zhejiang Province,enrolling patients who underwent daytime lung cancer surgery between October 2023 and January 2024. Postoperative symptoms were assessed using a lung cancer symptom scale on days 1,3,14,and 30 after discharge. Group-Based Trajectory Modeling(GBTM) was used to identify the post-discharge symptom trajectory categories among patients. Patient characteristics among different trajectory groups were compare,and the mean symptom response index was used to analyze the longitudinal changes of individual postoperative symptoms. Results Three trajectory groups were identified:mild symptoms-slowly decreasing group(n=184, 89.32%),severe symptoms-rapidly decreasing group(n=19,9.22%),and mild symptoms-worsening group(n=3,1.46%). Significant differences were observed among these post-discharge symptom trajectory groups in terms of age,surgical approach,and tumor type(P<0.05). On the first day after discharge,cough and pain were the most common symptoms,occurring in 180 cases(87.38%) and 197 cases(95.63%) respectively. Cough remained the predominant symptom on day 30 post-discharge(n=129,62.62%). In the mean symptom response index,constipation increased from 7.9 on day 1 to 9.2 on day 3,while dyspnea increased from 2.7 on day 1 to 6.7 on day 14. Conclusion There is significant heterogeneity in the dynamic symptom changes after discharge among daytime lung cancer surgery patients. Medical and nursing staff can formulate targeted care strategies based on differences in patient characteristics across the trajectory groups and changes in the mean symptom response index for individual symptoms,thereby improving patient rehabilitation and providing high-quality,whole-course nursing care.
| [1] | Bray F, Laversanne M, Sung H, et al. Global cancer statistics 2022:GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J]. CA Cancer J Clin, 2024, 74(3):229-263. |
| [2] | Panel EC, Kidane B, Bott M, et al. The American association for thoracic surgery(AATS) 2023 expert consensus document:staging and multidisciplinary management of patients with early-stage non-small cell lung cancer[J]. J Thorac Cardiovasc Surg, 2023, 166(3):637-654. |
| [3] | 谢冬, 陈昶, 朱余明, 等. 日间手术及加速康复外科用于早期肺癌微创外科517例的探索与实践[J/OL]. 中国胸心血管外科临床杂志, 2021:1-7. (2021-01-14). http://kns.cnki.net/KCMS/detail/detail.aspx?filename=ZXYX20210113008&dbname=CJFD&dbcode=CJFQ. |
| Xie D, Chen C, Zhu YM, et al. Exploration and practice of day surgery and enhanced recovery after surgery in minimally invasive surgery for 517 cases of early-stage lung cancer[J/OL]. China Ind Econ, 2021:1-7. (2021-01-14). http://kns.cnki.net/KCMS/detail/detail.aspx?filename=ZXYX20210113008&dbname=CJFD&dbcode=CJFQ. | |
| [4] | 国务院办公厅关于推动公立医院高质量发展的意见[EB/OL]. (2021-05-14)[2024-03-20]. https://www.gov.cn/gongbao/content/2021/content_561894.htm. |
| Opinions of the General Office of the State Council on Promoting high-quality development of public hospitals[EB/OL]. (2021-05-14)[2024-03-20]. https://www.gov.cn/gongbao/content/2021/content_561894.htm. | |
| [5] | Lowery AE, Krebs P, Coups EJ, et al. Impact of symptom burden in post-surgical non-small cell lung cancer survivors[J]. Support Care Cancer, 2014, 22(1):173-180. |
| [6] | Hirpara DH, Coburn NG, Darling GE, et al. Symptom assessment following surgery for lung cancer:a Canadian population-based retrospective cohort study[J]. Ann Surg, 2023, 277(2):e428-e438. |
| [7] | 关于印发进一步改善护理服务行动计划(2023—2025年)的通知[EB/OL]. (2023-06-05)[2024-04-20]. https://www.gov.cn/zhengce/zhengceku/202306/content_688730.htm,2024-11-28. |
| Notice on Issuing the Action Plan for Further Improvement of Nursing Services(2023-2025)[EB/OL]. (2023-06-05)[2024-04-20]. https://www.gov.cn/zhengce/zhengceku/202306/content_688730.htm,2024-11-28. | |
| [8] | Tang L, Yu HF, Dai W, et al. Symptom trajectories informing patient care after lung cancer surgery:a longitudinal patient-reported outcome study[J]. Ann Surg Oncol, 2023, 30(5):2607-2617. |
| [9] | 韩娜菲, 贺红, 袁华娣, 等. 日间肺癌手术患者出院后症状纵向变化及护理对策研究[J]. 中华护理杂志, 2025, 60(4):432-438. |
| Han NF, He H, Yuan HD, et al. Longitudinal changes of symptoms and nursing strategies of patients under daytime lung cancer surgery after discharge[J]. Chin J Nurs, 2025, 60(4):432-438. | |
| [10] | 何雯倩, 郭园丽, 王连珂, 等. 首发脑卒中患者护理依赖轨迹的潜在类别及影响因素分析[J]. 中华护理杂志, 2023, 58(7):829-835. |
| He WQ, Guo YL, Wang LK, et al. Analysis of potential categories and influencing factors of care dependency trajectories among first stroke patients[J]. Chin J Nurs, 2023, 58(7):829-835. | |
| [11] | 四川省护理学会. T/SCNA 0001-2022. 日间手术中心护理质量安全管理[S]. 2022. |
| Nursing Association of Sichuan Province. T/SCNA 0001-2022. Nursing quality and safety management of day surgery center[S]. 2022. | |
| [12] | 中华医学会麻醉学分会. 日间手术麻醉指南[J]. 中华医学杂志, 2023, 103(43):3462-3471. |
| Anesthesiology Branch of Chinese Medical Association. Guidelines for anesthesia management for ambulatory surgery[J]. Natl Med J China, 2023, 103(43):3462-3471. | |
| [13] | 周坤, 车国卫. 肺癌患者术后症状量表的建立和评价[J]. 中国循证医学杂志, 2020, 20(10):1157-1163. |
| Zhou K, Che GW. Establishment and evaluation of postoperative symptom inventory for patients with lung cancer[J]. Chin J Evid Based Med, 2020, 20(10):1157-1163. | |
| [14] | 张崎, 戴维, 魏星, 等. 患者报告结局量表在肺癌外科中的应用现状[J]. 中国胸心血管外科临床杂志, 2024, 31(4):606-612. |
| Zhang Q, Dai W, Wei X, et al. Application status of patient-reported outcome scale in lung cancer surgery[J]. Chin J Clin Thorac Cardiovasc Surg, 2024, 31(4):606-612. | |
| [15] | Saito T, Hamakawa A, Takahashi H, et al. Symptom severity trajectories and distresses in patients undergoing video-assisted thoracoscopic lung resection from surgery to the first post-discharge clinic visit[J]. PLoS One, 2023, 18(2):e0281998. |
| [16] | Zhang JY, Zhao HX, Lü LM, et al. Uniportal thoracoscopic pulmonary lobectomy in the treatment of lung cancer[J]. Pak J Med Sci, 2020, 36(2):182-186. |
| [17] | Wu W, Wang DY, Liu Y, et al. Comparison of ultrasound-guided subtransverse process interligamentary plane block with paravertebral block for postoperative analgesia in thoracic surgery:protocol for a randomised non-inferiority trial[J]. BMJ Open, 2024, 14(3):e082135. |
| [18] | Hugoy T, Lerdal A, Rustoen T, et al. Predicting postoperative fatigue in surgically treated lung cancer patients in Norway:a longitudinal 5-month follow-up study[J]. BMJ Open, 2019, 9(9):e028192. |
| [19] | Nan J, Duan Y, Wu S, et al. Perspectives of older adults,caregivers,healthcare providers on frailty screening in primary care:a systematic review and qualitative meta-synthesis[J]. BMC Geriatr, 2022, 22(1):48. |
| [20] | Siriwardhana DD, Hardoon S, Rait G, et al. Prevalence of frailty and prefrailty among community-dwelling older adults in low-income and middle-income countries:a systematic review and meta-analysis[J]. BMJ Open, 2018, 8(3):e018195. |
| [21] | Chen KY, Yang DD, Li F, et al. Changes in the symptom clusters of elderly patients with lung cancer over the course of postoperative rehabilitation and their correlation with frailty and quality of life:a longitudinal study[J]. Eur J Oncol Nurs, 2023,67:102388. |
| [22] | Komici K, Bencivenga L, Navani N, et al. Frailty in patients with lung cancer:a systematic review and Meta-analysis[J]. Chest, 2022, 162(2):485-497. |
| [23] | 李曦哲, 矫文捷, 龙浩, 等. 《机器人胸外科日间手术临床实践专家共识》解读[J]. 机器人外科学杂志(中英文), 2024, 5(1):109-112. |
| Li XZ, Jiao WJ, Long H, et al. Interpretation of the expert consensus on the clinical practice of robotic-assisted thoracic day surgery[J]. Chin J Rob Surg, 2024, 5(1):109-112. | |
| [24] | von Reibnitz D, Shaikh F, Wu AJ, et al. Stereotactic body radiation therapy(SBRT) improves local control and overall survival compared to conventionally fractionated radiation for stage I non-small cell lung cancer(NSCLC)[J]. Acta Oncol, 2018, 57(11):1567-1573. |
| [25] | 陈国标, 杜巍, 周建平, 等. 肺癌病例分布及病理特征趋势分析[J/OL]. 中华肺部疾病杂志(电子版), 2021, 14(5):590-592. |
| Chen GB, Du W, Zhou JP, et al. Analysis on the trend of lung cancer case distribution and pathological features[J/OL]. Chin J Lung Dis(Electron Ed), 2021, 14(5):590-592. | |
| [26] | Dai W, Chang S, Pompili C, et al. Early postoperative patient-reported outcomes after thoracoscopic segmentectomy versus lobectomy for small-Sized peripheral non-small-cell lung cancer[J]. Ann Surg Oncol, 2022, 29(1):547-556. |
| [27] | Brown TJ, Keshvani N, Gupta A, et al. Rates of appropriate laxative prophylaxis for opioid-induced constipation in veterans with lung cancer:a retrospective cohort study[J]. Support Care Cancer, 2020, 28(11):5315-5321. |
| [28] | Yamamotová A. Endogenous antinociceptive system and potential ways to influence It[J]. Physiol Res, 2019, 68(Suppl 3):S195-S205. |
| [29] | 刘桂先. 非小细胞肺癌术后症状及纵向变化的研究[D]. 泸州: 西南医科大学, 2023. |
| Liu GX. Study on postoperative symptoms and longitudinal changes of non-small cell lung cancer[D]. Luzhou: Southwest Medical University, 2023. | |
| [30] | 覃梦霞, 潜艳, 徐蓉, 等. 基于互联网+肺康复全程健康教育在肺癌手术患者中的应用[J]. 中华护理杂志, 2023, 58(15):1808-1814. |
| Qin MX, Qian Y, Xu R, et al. The application of Internet based whole health education of pulmonary rehabilitation in patients undergoing lung cancer surgery[J]. Chin J Nurs, 2023, 58(15):1808-1814. |
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