Objective  To explore the training methods for emergency department nurses to respond to COVID-19 and  evaluate  the  effects.  Methods   112  nurses  in  our department  were  trained  through  skill training,theoretical knowledge training and patient consultation and question-answering training. The assessment scores before and after the training were compared and analyzed. Results  The percentage of nurses who mastered the theory knowledge of novel coronavirus increased from 25.9% to 98.2% after training (P<0.001).The correct rates of wearing and taking off protective clothes,and the pharyngeal swab skill were improved from 42.9% to 99.1% after training  (P<0.001).The differences were statistically significant. Conclusion  Our department nurses' theoretical knowledge and protective skills for COVID-19 have been improved after training and it achieves the expected training goals.