Objective To summarize the best evidence for safe infusion of vasoactive drugs in adult patients，and to provide evidence support for clinical nursing work. Methods We searched UpToDate，BMJ Best Practice，Joanna Briggs Institute library，Cochrane Library，National Guideline Clearinghouse，Centers for Disease Control and Preven- tion，National Institute for Health and Care Excellence，Guideline International Network，CINAHL，Embase，Registered Nurses’ Association of Ontario，UK Intensive Care Society，American Intravenous Nurses Society，PubMed，Web of Science，CNKI，Wanfang Database，VIP，Chinese Nursing Association，SinoMed，Yimaitong to collect guidelines，expert consensuses，group standards，systematic reviews，evidence summaries and original study on vasoactive drug infusionin adult patients. The retrial limit was from January 1，2013 to March 10，2023.Literature quality evaluation and ev- idence screening were conducted independently by two researchers with evidence-based nursing research back- ground，and the evidence was classified and integrated by the team after summary. Results A total of 12 litera- tures were included，and 29 pieces of evidence were summarized from five dimensions：training and education，evalu- ation，vascular access selection，infusion scheme and complications management. Conclusion This study summarizes the best evidence of vasoactive drug infusion in adult patients，which can provide medical staff with scientific infu- sion regimen，ensure patient safety and improve the quality of care.