To summarize the perioperative nursing experience of a patient with ovarian cancer with cerebral in- farction as the first symptom. In view of the patient’s critical and complex condition，being prone to thrombosis and bleeding during perioperative period，the increasing risk of postoperative complications，the patient’s psychological re- habilitation，limbs rehabilitation and other problems，the establishment of a multidisciplinary cooperation team was adopted to manage the whole process. We fully assessed the condition before surgery and formulated a nursing plan，did a good job of medication care during bridging anticoagulation，actively prevented pulmonary embolism and new cerebral infarction，used traditional Chinese medicine enema method to prevent postoperative intestinal obstruc- tion，encourage family members to participate in patient psychological care to promote recovery. Through active treatment and nursing，the patient was discharged from the hospital on the 9th day after surgery. After 6 months of follow-up，the recovery was good.