To summarize the nursing experience of 3 children with acute liver failure caused by neuroblastoma amplified sequence gene mutations. In view of the problems of hepatic encephalopathy caused by hyperammonemia， high fever and increased catabolism caused by infection，and post-discharge care in this group of children，we adopted strict monitoring of awareness to evaluate the development of hepatic encephalopathy，and appropriate blood purification methods in a timely manner to quickly lower blood ammonia；prevention and control of infection， especially body temperature management；strengthening nutritional support；regular follow-up to avoid recurrence of acute liver failure. After rapid treatment and careful care，the three children were discharged from the hospital in stable condition and recovered well during 3 months of follow-up after discharge.