To summarize the nursing experience of segmented nutrition therapy in a patient with severe polytrauma and entero-atmospheric fistula. In view of the difficulty of wound care around entero-atmospheric fistula，the disruption of the continuity of the digestive system，and the difficulty of nutritional support，the fistula and intestinal tube protection at the open abdomen with vacuum-assisted closure technology was adopted，combined with segmented enteral nutrition therapy and nursing of intestinal fluid reinfusion treatment. The intestinal fluid from the fistula was drained smoothly，and abdominal wall defect healed well in the later period，the enteral nutrition support reached the target amount. After 60-day hospitalization，the patient finally recovered and was discharged.