To summarize the nursing experience of weaning in a ventilated patient with Lemierre syndrome and secondary glottis imperfection. In view of the difficulty of weaning and the high risk of re- intubation，we adopted respiratory support in acute phase，risk assessment before extubation and multi-disciplinary extubation strategy，post-extubation observation and emergency treatment，early warning assessment to balance bleeding and thrombosis，active infection control to prevent cross infection，staged rehabilitation training，goal-oriented nutritional support and positive psychological support and other measures. After 25 days of active treatment and nursing，the patient’s condition improved，transferred to the rehabilitation hospital for continue treatment. The patients were followed up for 3 months and his life returned to normal.