To summarize the nursing experience of 6 cases of lung transplantation patients with hybrid extracorporeal membrane oxygenation （ECMO）. In view of the complicated procedure of turn flow，difficulty of management and multiple safety risks in this group of patients with hybrid ECMO，the following targeted nursing measures were taken，including establishing a professional working mechanism for highly effective cooperation of doctors and nurses，precise flow regulation to ensure effective cardiopulmonary support，clear pipeline management to ensure patient safety，monitor of neurological symptoms through multiple channels and close monitoring of complications. With careful care，all patients had no related complications during ECMO transfer，and the machine was successfully removed.