Objective To construct physical restraint clinical practice guidelines which it is appropriate to use among adult patients admitted into intensive care units（ICU）with Chinese context. Methods Based on the CAN-IMPLEMENT approach,which integrated existing high-quality clinical practice guidelines and systematic review evidence,a multidisciplinary team of experts used Grades of Recommendation,Assessment,Development,and Evaluation （GRADE）,and Delphi method to achieve a consensus on the recommendations. Results 15 recommendations were developed for 11 critical clinical questions related to physical restraint reduction based on 8 clinical practice guidelines and 71 systematic reviews. Conclusion This guideline provides evidence in physical restraint management and minimization in ICU for practitioners focusing on nurses.