To summarize the nursing of septic shock caused by vibrio vulnifificus infection in a patient with sea fish puncture. In view of the patient’s special mechanism of injury，acute onset，rapid progress of the disease，critical condition and etc.，key points of nursing included early recognition and observation of vibrio vulnificus sepsis and predicted preparation of emergency treatment，fine fluid resuscitation and management to prevent septic shock， reasonable use of antibiotics to prevent infection from worsening，enhanced care of different types of infected wounds and close observation of blood circulation of the affected limb to promote wound healing and the recovery of limb function，psychological support and nutritional nursing at the same time. After 58 days of active treatment and care，the patient recovered and was discharged from the hospital. The patient was followed up for 6 months， she was in good condition，the function of the right lower limb recovered and can walk normally.