To summarize the postoperative nursing care in a patient with short bowel syndrome and antithrombin Ⅲ deficiency undergoing living donor small intestinal transplantation. To address recurrent bleeding during the early postoperative anticoagulation period，and multiple severe postoperative complications，the following measures were implemented，including enhancing risk management and monitor for postoperative bleeding and thromboembolic events，early initiation of fluid resuscitation to optimize intestinal perfusion，dynamical assessment of graft intestinal function and implementation of stepwise nutritional support，comprehensive infection prevention with emphasis on intra-abdominal infections，establishment of electronic case records and implementing continuity of nursing care. Through the transplant team’s treatment and precision nursing，the patient was successfully discharged 36 days postoperatively. The patient was readmitted 61 days postoperatively for closure of the transplant stoma. 30-month follow-up after discharge has demonstrated good recovery.