To summarize the nursing experience for a child with congenital insensitivity to pain with anhidrosis complicated by sepsis and status epilepticus. Key interventions included dynamic condition assessment using the Phoenix Sepsis Score and early identification of sepsis high-risk state and vigilance against septic shock，multidisciplinary collaborative convulsion monitoring and emergency care，refined temperature management for anhidrosis-related dysregulation and advancing high fever risk prevention，addressing the issue of pain sensation loss by enhancing self-harm behavior protection to reduce infection and fracture risks，and family-centered discharge care guided by a care map. The child achieved stable condition and was discharged after 14 days of standardized intervention.