This report summarized the multidisciplinary collaborative nursing experience of a primigravida undergoing mid-pregnancy rectal cancer radical resection with fetal preservation. To address the core challenge of the dual treatment contradiction between oncologic radicality and strong demand for fetal preservation in the patient，and to solve the high risk of postoperative uterine contractions and premature birth，the dilemma of incision healing with abdominal pressure growth，perioperative abdominal pain differentiation，and multiple psychological crises，a nursing led multidisciplinary collaboration team has been established，to implement a tertiary uterine contraction warning system，tailored incision care，precise identification of pain sources and optimization of management，and key-node based psychological support. After 19 days of treatment，the patient was discharged and subsequently delivered a 2，100 g male infant by cesarean 60 days after the surgery，with both mother and infant in good health.