This paper summarized the nursing experience of a lung transplant patient with rhabdomyolysis who underwent continuous renal replacement therapy. For elderly patient with poor multi-organ functional reserve，high risk of abnormal coagulation function，and high risk of infection under immunosuppression，the following nursing measures were taken：early initiation of continuous veno-venous hemodiafiltration mode treatment，using high-flux filters to enhance myoglobin clearance；implementing a stepwise anticoagulation plan，optimizing the anticoagulation strategy；strengthening catheter maintenance to prevent infection. After 30 days of individualized treatment and nursing，the patient’s creatine kinase decreased from 12，450 U/L to 287 U/L，the lower limb muscle strength recovered from grade 2 to grade 4，no bleeding or infection complications occurred，and the patient smoothly transitioned to intermittent renal replacement therapy，ultimately achieving stable discharge.