To summarize the nursing experience of a child with ryanodine receptor 2 gene variant-related catecholaminergic polymorphic ventricular tachycardia complicated with cardiac arrest. Given the nursing challenges of prolonged ischemic hypoxia，rapid disease progression，recurrent malignant arrhythmia，and highly sensitive emotional stimuli in this pediatric patient，we implemented rapid initiation of individualized high-quality targeted temperature management，conducted extracorporeal membrane oxygenation combined with prone ventilation therapy，promptly identified malignant arrhythmia，quickly activated the emergency response system，adopted multidimensional emotional stimulus avoidance strategies to reduce malignant arrhythmia episodes，while initiating progressive motor rehabilitation early. After 31 days of meticulous nursing，the child was successfully transferred to another hospital for rehabilitation therapy. During the 6-month follow-up period，no further malignant arrhythmia events occurred.