To summarize the nursing experience of a premature infant with bronchopulmonary dysplasia and congenital pulmonary bullae at a gestational age of 23⁺¹ week with a survival limit. In response to the infant with extremely premature birth，low body weight，poor lung conditions and extremely high surgical risks，key points of nursing care included individualized airway care，avoiding unplanned extubation，formulation of the rescue process for pulmonary bullae，attaching importance to the nursing of closed thoracic drainage，dynamic monitoring of infection indicators，implementation of family integrated care and other nursing measures. The infant was discharged from the hospital smoothly after 158 days of hospitalization，with stable breathing and feeding tolerance. She has been followed up for more than 8 months. Her weight has increased to 8.9 kg and she was gradually catching up. Her general condition was good.