Objective To investigate the current level of perceived professional benefits among pediatric nurses and identify influencing factors，providing evidence for improving their professional mental health. Methods A cross sectional online survey was conducted from August to December 2022 using convenience sampling，using a general information questionnaire and the Nurse’s Perceived Professional Benefits（NPPB）scale. A total of 529 pediatric nurses from 130 children’s hospitals，maternal and child health hospitals，and general hospitals across 31 cities in 15 provinces were enrolled. Univariate analysis and multiple linear regression were performed to identify influencing factors. Results The mean NPPB score was 140.28±19.21，exceeding the theoretical median of 132，indicating a moderate to high level of professional benefit perception. Multiple regression analysis revealed that professional title （β=0.196，P<0.001），relationship with preceptors（β=-0.224，P<0.001），relationship with colleagues（β=-0.106，P=0.039），reasons for choosing nursing as a career（β=-0.176，P<0.001），and receipt of humanistic care education（β= -0.126，P=0.001） were independent predictors. Conclusion Pediatric nurses report a generally favorable level of perceived professional benefits，yet room for improvement remains. Nursing administrators should enhance psychological support and strengthen humanistic care training to improve professional recognition and ensure workforce stability.