This article summarized the nursing experience of a patient with severe meningoencephalitis caused by porcine herpesvirus infection，accompanied by acute retinal necrosis in both eyes. While providing antiviral，anti-infective，high-dose hormone shock therapy，sedation，mechanical ventilation and other treatments，we also observed the condition well. We implemented postoperative care for eye surgery，contact isolation care，pulmonary rehabilitation care，and multiple targeted nursing measures. The patient was clinically cured and discharged on the 22nd day after admission.