Objective To investigate the current status of postoperative quality of life of pediatric liver transplant recipients and to analyze its related factors. Methods A total of 273 pediatric liver transplant recipients who were followed up in the outpatient clinic of a tertiary class A hospital in Zhejiang Province from August 2023 to September 2024 were selected by continuous sampling method，and the quality of life survey was conducted using the general information questionnaire and the Pediatric Quality of Life InventoryTM（PedsQLTM） 3.0 transplant module. Pearson correlation analysis was used to analyze the factors affecting the quality of life of pediatric liver transplant recipients. Results A total of 281 questionnaires were distributed，and 273 qualified questionnaires were recovered. Among 273 pediatric liver transplant recipients,the total quality of life score was 72.28（61.41，86.41） for recipients aged 2~4 years，68.48（58.15，75.00） for recipients aged 5~7 years, and 71.96（60.98，94.57） for recipients aged 8~18 years. The results of univariate analysis showed that the total quality of life score of urban recipients was higher than that of rural recipients（P<0.05），and the quality of life of recipients with high monthly household income was higher than that of recipients with low monthly household income（P<0.05）. There were statistically significant differences in the three dimensions of “adverse drug reactions”“worry” and “self-perception of appearance” of questionnaires among different age groups（P<0.05）. The results of correlation analysis showed that there was positively correlation between post-transplant time and two dimensions of “drug compliance” and “post-transplant social relationship”（r=0.214，P<0.001；r=0.167，P=0.006），and the height of the recipient was positively correlated with the two dimensions of “adverse drug reaction” and “anxiety treatment”（r=0.242，P<0.001；r=0.145，P=0.016），and the weight of the recipient was positively correlated with the two dimensions of “adverse drug reaction” and “anxiety treatment”（r=0.183，P=0.002；r=0.151，P=0.013）. The results of Z-score method showed that 48 recipients had growth and development disorders，including 46 cases at the age of 2~4 years old，and 1 case at the age of 5~7 years and 1 case at the age of 8~18 years. Conclusion The quality of life of pediatric liver transplant recipients needs to be improved. Different resident types and monthly household income were the influencing factors for the quality of life of pediatric liver transplant recipients. The time after transplantation，height and weight are all related to the quality of life.