Abstract: Objective To construct a scheme for prevention of lower limb ischemia in patients with venous-arte- rial extracorporeal membrane oxygenation，which can further reduce the occurrence of lower limb ischemia and iden- tify the occurrence of lower limb ischemia in the early stage，so as to shorten the time of ischemic complications and improve the quality of life. Methods To construct literature review on the venous-arterial extracorporeal mem- brane oxygenation related lower limb ischemia prevention program，20 experts were queried twice using the Delphi method to form the final plan for the prevention of lower limb ischemia in patients with venous-arterial extracorpo- real membrane oxygenation. Results The response rates of the two rounds of expert consultation were 100%，the authority coefficients were 0.83 and 0.87，and the variation coefficients of each item of the two rounds of expert consultation were 0.05-0.12 and 0.07-0.21，respectively，Kendall’s harmonic coefficients were 0.121（χ2=89.798，P<0.001） and 0.193 （χ2=141.308，P<0.001），respectively. Finally，a 4-dimensional，26-item venous-arterial extracorporeal mem- brane oxygenation related lower limb ischemia prevention protocol was formed. Conclusion The prevention protocol for venous-arterial extracorporeal membrane oxygenation related lower limb ischemia is scientific and feasible. It can reduce the occurrence of lower limb ischemia and promote the early recognition of lower limb ischemia，to ensure the quality of life of patients.

Key words: Extracorporeal Membrane Oxygenation, Lower Extremity, Ischemia, Delphi Technique, Evidence-Based Nursing