蔡莎莎、何杨梦圆、张美、张明月：文献检索与筛选、质量评价、证据提取、论文撰写；帅琴燕：证据校审；项新月：论文修改；黄丽华：方法学指导、研究指导
收稿日期: 2025-08-26
网络出版日期: 2026-06-02
Evidence summary for the management of mechanical ventilation in patients with sepsis
Received date: 2025-08-26
Online published: 2026-06-02
目的 检索和评价脓毒症患者机械通气管理的相关文献，对其进行总结，为临床护理工作提供循证依据。方法 根据“6S”证据资源金字塔模型，检索计算机决策系统、指南网站、专业协会网站、循证数据库、原始研究数据库中有关脓毒症患者机械通气管理的相关文献，检索时限从建库至2025年8月3日。3名研究者对纳入文献进行筛选和评价，提取相关证据。 结果 纳入14篇文献，其中指南6篇、临床决策2篇、专家共识5篇、系统评价1篇，分别从开启时机、监测评估、氧合目标、机械通气策略、注意事项5个方面形成32条最佳证据。 结论 该研究总结了脓毒症患者机械通气护理管理过程的最佳证据，为医护人员制订规范有效的护理措施、保障脓毒症患者早期恢复提供循证依据。
蔡莎莎 , 帅琴燕 , 何杨梦圆 , 张美 , 项新月 , 张明月 , 黄丽华 . 脓毒症患者机械通气管理的最佳证据总结[J]. 中华急危重症护理杂志, 2026 , 7(6) : 740 -747 . DOI: 10.3761/j.issn.2096-7446.2026.06.018
Objective To retrieve and evaluate literature on the management of mechanical ventilation in patients with sepsis，summarize the findings，and provide an evidence-based basis for clinical nursing practice. Methods Based on the 6S evidence resource pyramid model，relevant literature on the management of mechanical ventilation in patients with sepsis was searched from computerized decision-making systems，guideline websites，professional society websites，evidence-based databases，and original research databases，with the search period ranging from the inception of the database to August 3，2025. Three Researchers screened and evaluated the included literature to extract relevant evidence. Results 14 articles were included，comprising 6 guidelines，2 clinical decisions，5 expert consensuses，and a systematic review. Thirty-two best practice recommendations were synthesized across five aspects：timing of initiation，monitoring and assessment，oxygenation goals，ventilation strategies，and precautions，respectively. Conclusion This study provides a summary of the best evidence for the nursing management of mechanical ventilation in patients with sepsis. It offers an evidence-based foundation for healthcare professionals to develop standardized and effective nursing interventions and facilitate the early recovery of patients with sepsis.
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