收稿日期: 2024-11-25
网络出版日期: 2025-09-25
Nursing care for a patient with plasma cell disease undergoing chimeric antigen receptor T-cell immunotherapy complicated with cytokine release syndrome
总结1例浆细胞疾病患者行嵌合抗原受体T细胞免疫治疗后并发细胞因子释放综合征的护理体会。针对患者出现的意识淡漠、畏寒高热、血压下降、三系血细胞减少等临床表现，采取严密病情监测、及时启动应急预案、循环支持、连续性肾脏替代治疗、感染预防等综合护理措施，患者成功救治并顺利出院，随访生活质量良好。
关键词： 嵌合抗原受体T细胞疗法; 细胞因子释放综合征; 危重病护理
李影 , 朱岩 , 曾妃 . 浆细胞疾病患者行嵌合抗原受体T细胞免疫治疗并发细胞因子释放综合征的护理[J]. 中华急危重症护理杂志, 2025 , 6(10) : 1220 -1222 . DOI: 10.3761/j.issn.2096-7446.2025.10.012
This article summarized the nursing experience of a patient with plasma cell disease who developed cytokine release syndrome（CRS） following chimeric antigen receptor T-cell（CAR-T） therapy. The patient exhibited severe clinical manifestations of CRS，including altered mental status，chills with high fever，hypotension，and pancytopenia. A comprehensive nursing approach was implemented，which included rigorous monitoring of the patient’s condition，prompt initiation of emergency response protocols，circulatory support，continuous renal replacement therapy（CRRT），and infection prevention. As a result of these measures，the patient was successfully treated and discharged. Follow-up revealed that the patient had a good quality of life.
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