目的 编制血管活性药物输注护理知信行问卷并检验其信效度。方法 以知信行理论为框架，通过文献分析、专家咨询、问卷项目分析以及预调查形成血管活性药物输注护理知信行初始问卷。采用便利抽样法，于2024年2月—6月选取四川省6所三级甲等和3所二级甲等医院的239名从事急危重症、心血管护理等专业的临床护士开展调查，进行信效度检验；从中便利抽取20名护士，两周后进行第2次调查，以测量重测信度。结果 形成的问卷包括3个维度共33个条目，其中知识维度15个条目、态度维度5个条目、行为维度13个条目，探索性因子分析显示，3个公因子的累计方差贡献率为78.03%，各条目在所属公因子上的载荷为0.56~0.89；问卷的条目水平内容效度指数为0.91~1.00，问卷整体的平均内容效度指数为0.98。问卷的Cronbach’s α系数为0.974，各维度的Cronbach’s α系数为0.965~0.979；问卷的重测信息组内相关系数为0.889，各维度的组内相关系数为0.890~0.989。结论 血管活性药物输注护理知信行问卷具有良好的信效度，可作为测评临床护士血管活性药物输注护理知信行水平的调查工具。

Objective To develop and test the reliability and validity of a Knowledge，Attitude，and Practice （KAP） Questionnaire for the Nursing Care of Vasoactive Agents Infusions. Methods Using the KAP theory framework，an initial questionnaire was developed through literature review，expert panel，item analysis，and a pilot survey. A convenience sample was used to select 239 clinical nurses specializing in critical care and cardiovascular nursing from six tertiary and three secondary hospitals in Sichuan Province from February to June 2024. The reliability and validity of the questionnaire were tested. Additionally，20 participants were re-surveyed two weeks after the initial round to gather test-retest reliability data. Results The final questionnaire comprised 33 items under three dimensions，including 15 items on knowledge，5 on attitude and 13 on practice. Exploratory factor analysis（EFA） showed that the cumulative variance contribution rate of the three common factors was 78.03%，with item loadings ranging from 0.56 to 0.89. The item-level content validity index（I-CVI） ranged from 0.91 to 1.00，and the scale-level content validity index（S-CVI/Ave） was 0.98. The Cronbach’s alpha coefficient for the entire questionnaire was 0.974，with each dimension’s Cronbach’s alpha ranging from 0.965 to 0.979. The intraclass correlation coefficient（ICC） for test-retest reliability was 0.889 for the entire questionnaire，and it ranged from 0.890 to 0.989 for each dimension. Conclusion The KAP Questionnaire for the Nursing Care of Vasoactive Agents Infusions demonstrates excellent reliability and validity，making it a suitable tool for assessing clinical nurses’ knowledge，attitudes，and practices regarding the nursing care of vasoactive agents infusions.