To summarize the emergency nursing experience of sudden cardiac arrest in 13 patients with acute myocardial infarction during emergency percutaneous coronary intervention. According to the characteristics of patients such as rapid disease progression，repeated cardiac arrest，unstable circulation and etc.，strict disease monitoring，early recognition of the symptoms of cardiac arrest，and rapid implementation of high-quality cardiopulmonary resuscitation were adopted. The nurses initiated the hospital emergency response system， multidisciplinary emergency team was set to carry out advanced life support treatment，and cooperated with doctors to quickly build extracorporeal membrane oxygenation therapy. We also paid attention to nursing measures such as safe transfer and effective handover in the hospital. Among the 13 patients，8 were discharged after condition was improved，3 gave up treatment and 2 died.