ISSN 2097-6046（网络）
ISSN 2096-7446（印刷）
CN 10-1655/R
主管：中国科学技术协会
主办：中华护理学会
中华急危重症护理杂志

中华急危重症护理杂志 >

2026 , Vol. 7 >Issue 6: 714 - 716

DOI: https://doi.org/10.3761/j.issn.2096-7446.2026.06.014

重症护理研究

进行性家族性肝内胆汁淤积症患儿行亲体肝移植的术后护理

  • 王燕 ,
  • 卢芳燕 ,
  • 刘元 ,
  • 王芳
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  • 浙江大学医学院附属第一医院肝移植中心 杭州市 310003
王燕：女，本科，副主任护师，护士长，E-mail：316781716@qq.com
第一联系人：

王燕：论文撰写；卢芳燕：研究指导、论文修改、经费支持；刘元、王芳：研究实施、循证分析

*卢芳燕，E-mail：2196032@zju.edu.cn

收稿日期: 2025-07-08

  网络出版日期: 2026-06-02

基金资助

浙江大学“双一流”建设护理优势特色学科科研培育基金(HL2024020)

收起

Postoperative care of children with progressive familial intrahepatic cholestasis undergoing parental liver transplantation

  • WANG Yan ,
  • LU Fangyan ,
  • LIU Yuan ,
  • WANG Fang
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  • Liver Transplantation Center， the First Affiliated Hospital，Zhejiang University School of Medicine， Hangzhou， 310003， China

Received date: 2025-07-08

  Online published: 2026-06-02

Supported by

Zhejiang University ‘Double First Class’ Nursing Advantage and Characteristic Discipline Research Cultivation Fund(HL2024020)

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摘要

总结2例进行性家族性肝内胆汁淤积症患儿行亲体肝移植的术后护理体会。针对患儿胆汁淤积严重、存在顽固性瘙痒、营养不良及代谢紊乱等问题，护理要点包括：建立胆汁淤积的动态监测体系；强化顽固性皮肤瘙痒的综合干预；实施个体化营养管理方案；加强急性排斥反应的早期识别与处理；落实代谢性骨病的预防护理。经过积极治疗和精心护理，2例患儿术后康复出院，随访8~12个月余，预后良好。

关键词： 胆汁淤积; 肝内; 儿科护理学; 肝移植; 重症监护病房; 危重病护理

本文引用格式

王燕 , 卢芳燕 , 刘元 , 王芳 . 进行性家族性肝内胆汁淤积症患儿行亲体肝移植的术后护理[J]. 中华急危重症护理杂志, 2026 , 7(6) : 714 -716 . DOI: 10.3761/j.issn.2096-7446.2026.06.014

Abstract

To summarize the postoperative nursing experience of two children with progressive familial intrahepatic cholestasis who underwent parental liver transplantation. For children with severe cholestasis，persistent itching，malnutrition，and metabolic disorders，the nursing key points included establishing a dynamic monitoring system for cholestasis，strengthening comprehensive interventions for persistent skin itching，implementing individualized nutritional management plans，enhancing early identification and management of acute rejection reactions，implementing preventive care for metabolic bone disease. After active treatment and careful nursing，two children recovered after the surgery and were discharged from the hospital，the follow-up of more than 8~12 month showed good prognosis.

Key words： Cholestasis; Intrahepatic; Pediatric Nursing; Liver Transplantation; Intensive Care Units; Critical Care Nursing

参考文献

[1] 白洁, 郑素军, 段钟平. 进行性家族性肝内胆汁淤积症的临床特征及诊疗思路[J]. 中华肝脏病杂志, 2021, 29(11):1128-1131.
  Bai J, Zheng SJ, Duan ZP. Clinical features and diagnosis and treatment of progressive familial intrahepatic cholestasis[J]. Chin J Hepatol, 2021, 29(11):1128-1131.
[2] 许玲芬, 孙梅. 进行性家族性肝内胆汁淤积症[J]. 中国小儿急救医学, 2020, 27(7):490-493.
  Xu LF, Sun M. Progressive familial intrahepatic cholestasis[J]. Chin Pediatr Emerg Med, 2020, 27(7):490-493.
[3] 李东丹, 张晶, 王国丽, 等. 儿童进行性家族性肝内胆汁淤积症4例临床分析[J]. 中国实用儿科杂志, 2021, 36(4):295-298.
  Li DD, Zhang J, Wang GL, et al. Clinical analysis of 4 cases of progressive familial intrahepatic cholestasis in children[J]. Chin J Pract Pediatr, 2021, 36(4):295-298.
[4] 罗毅. 中国儿童肝移植操作规范(2019版)[J]. 中华移植杂志(电子版), 2019, 13(3):181-186.
  Luo Y. Technical specification for pediatric liver transplan-tation in China(2019 edition)[J]. Chin J Transplant Electron Ed, 2019, 13(3):181-186.
[5] 中华医学会肝病学分会, 陆伦根, 蔡晓波, 等. 胆汁淤积性肝病管理指南(2021)[J]. 中华肝脏病杂志, 2022(3):253-263.
  Chinese Medical Association Hepatology Branch, Lu LG, Cai XB, et al. Guidelines on the management of cholestasis liver diseases(2021)[J]. Chin J Hepatol, 2022(3):253-263.
[6] 王芳, 卢芳燕. 1例鸟氨酸氨甲酰基转移酶缺乏症患儿行肝移植的围手术期护理[J]. 中华护理杂志, 2022, 57(13):1618-1622.
  Wang F, Lu FY. Perioperative nursing care of a child with otrnithine transcarbamlase deficiency undergoing liver trans-plantation[J]. Chin J Nurs, 2022, 57(13):1618-1622.
[7] 马秋实, 李彤, 王娜. 熊去氧胆酸与苯巴比妥治疗新生儿胆汁淤积症疗效观察[J]. 实用药物与临床, 2019, 22(2):162-165.
  Ma QS, Li T, Wang N. Efficacy of ursodeoxycholic acid and phenobarbital in the treatment of neonatal cholestasis[J]. Pract Pharm Clin Rem, 2019, 22(2):162-165.
[8] 中国研究型医院学会加速康复外科专业委员会, 梁廷波, 白雪莉, 等. 儿童肝移植围手术期管理专家共识[J]. 中华外科杂志, 2021, 59(3):179-191.
  Enhanced Recovery After Surgery Committee of Chinese Re-search Hospital Association, Liang TB, Bai XL, et al. Expert consensus of perioperative management in pediatric liver trans-plantation[J]. Chin J Surg, 2021, 59(3):179-191.
[9] 王燕, 卢芳燕, 王芳. 丙酸血症患儿行亲体肝移植的术后护理[J]. 中华急危重症护理杂志, 2023, 4(4):347-349.
  Wang Y, Lu FY, Wang F. Postoperative nursing of children with propionic acidemia undergoing parent-child liver trans-plantation[J]. Chin J Emerg Crit Care Nurs, 2023, 4(4):347-349.
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