总结1例颈深部感染合并糖尿病酮症酸中毒并进展为纵隔脓肿患者的护理体会。针对患者在超声内镜引导下行细针活检穿刺术的手术配合要求高、感染控制难度大、咽喉部功能障碍，以及严重负性情绪等问题，采取多学科协作团队制订手术全流程管理方案、多元化护理降低感染风险、优化血糖管控、实施过渡式营养护理，以及运用音乐治疗和情绪焦点疗法强化心理支持等措施，患者住院第26天康复出院。2 个月后随访，患者恢复良好，已回归社会。

To summarize the nursing experience in managing a patient with deep neck infection complicated by diabetic ketoacidosis（DKA），which progressed to a malignant mediastinal abscess. Addressing challenges including high surgical coordination demands of endoscopic ultrasound-guided fine needle aspiration，significant difficulties in infection control，pharyngolaryngeal dysfunction，and severe negative emotions，a multidisciplinary team developed a comprehensive perioperative management plan. Interventions included a multidisciplinary approach to coordinate the entire surgical process，multifaceted nursing strategies to control infection risks，optimized glycemic management，transitional nutritional support，as well as music therapy and emotion-focused therapy to enhance psychological support. The patient was discharged successfully after 26 days. Follow-up at two months indicated favorable recovery and successful reintegration into society.