总结1例短肠综合征合并抗凝血酶Ⅲ缺乏症患者行活体小肠移植的术后护理体会。针对患者术后早期抗凝期间反复出血、术后并发症多且危重等问题，采取如下护理措施：强化风险防控，警惕术后出血/血栓并发症；早期实施液体复苏，优化肠道灌注；动态监测移植肠功能，实施序贯性营养；落实全程化感染防控，积极预防腹腔感染；建立电子化个案管理档案，开展延续性照护。经过移植团队的救治和精准化护理，患者术后第36天出院；术后第61天再次入院行移植肠造口关闭术。患者出院后随访共30个月，恢复良好。

To summarize the postoperative nursing care in a patient with short bowel syndrome and antithrombin Ⅲ deficiency undergoing living donor small intestinal transplantation. To address recurrent bleeding during the early postoperative anticoagulation period，and multiple severe postoperative complications，the following measures were implemented，including enhancing risk management and monitor for postoperative bleeding and thromboembolic events，early initiation of fluid resuscitation to optimize intestinal perfusion，dynamical assessment of graft intestinal function and implementation of stepwise nutritional support，comprehensive infection prevention with emphasis on intra-abdominal infections，establishment of electronic case records and implementing continuity of nursing care. Through the transplant team’s treatment and precision nursing，the patient was successfully discharged 36 days postoperatively. The patient was readmitted 61 days postoperatively for closure of the transplant stoma. 30-month follow-up after discharge has demonstrated good recovery.