总结1例灾难性抗磷脂综合征致肢端坏死患者的护理体会。针对患者病情危重、进展迅猛、多系统受累等问题，采取多学科协作应对灾难性抗磷脂综合征、血栓-出血平衡管理、多器官功能保护、截肢后综合管理等措施。患者病情得到有效控制，入院第7天成功转出ICU，入院第29天康复出院。随访显示，患者未出现出血或新发血栓等并发症，心理状态良好，已开始义肢适配训练。

This paper summarized the nursing experience of a patient with acral necrosis caused by catastrophic antiphospholipid syndrome. In response to the patient’s characteristics of critical condition，rapid progression and involvement of multiple systems，measures such as multidisciplinary collaboration to deal with catastrophic antiphospholipid syndrome，balance management of thrombosis and hemorrhage，protection of multiple organ functions，and comprehensive management after amputation were adopted. The patient’s condition was effectively controlled，she was successfully transferred out of the ICU after 7 days and discharged from the hospital after 22 days of recovery. Follow-up showed that there were no complications such as hemorrhage or new thrombosis，the patient’s mental state was good，and she had started prosthetic adaptation training.