目的 全面检索、评价和总结缺血性脑卒中急性期血压管理的最佳证据，为临床血压的管理和监测提供参考。 方法 按照证据金字塔“5S”模型，系统检索国内外各大数据库、相关循证资源库和专业协会网中所有相关证据，包括临床决策、最佳实践、证据总结、指南和系统评价。检索时限为建库至2024年12月10日。由2名研究者独立完成文献方法学质量评价和证据的提取与汇总。结果 共纳入22篇文献，包括2篇临床决策、4篇指南和16篇系统评价。从原则和目的、静脉溶栓、机械取栓、未治疗和恢复期血压管理5个维度提取了20条最佳证据。结论 该研究总结了缺血性脑卒中急性期血压管理的最佳证据，证据的质量和级别整体水平较高，对临床医护人员开展科学有效的血压管理具有指导意义，可结合临床工作实际情况制订针对性的血压管理方案，从而改善患者预后。

Objective To comprehensively search，evaluate and summarize the best evidence of blood pressure management in the acute phase of ischemic stroke，to provide reference for blood pressure management and monitoring. Methods Based on the 5S model of the evidence hierarchy，a systematic search was conducted across major domestic and international databases，relevant evidence-based resources，and professional association websites to retrieve all pertinent evidence，including clinical decision-making，best practices，evidence summaries，clinical guidelines，and systematic reviews. The search time limit was from the establishment of databases to December 10，2024. Two researchers independently evaluated the quality of the literature，extracted and summarized the evidence. Results A total of 22 studies were included，including 2 clinical decision-making resources，4 guidelines，and 16 systematic reviews. The best evidence included 20 recommendations in 5 aspects，including blood pressure management principles and objectives，blood pressure management during intravenous thrombolysis，mechanical thrombectomy，non-reperfusion treatment，and recovery phase management. Conclusion This study summarized the beat evidence of blood pressure management in the acute-phase of ischemic stroke. The overall level of the quality and level of the evidence is high，which has guiding significance for clinical medical staff to carry out scientific and effective blood pressure management. It can formulate targeted blood pressure management plans according to the actual situation of clinical work，and improve the blood pressure of patients.