目的 总结ICU机械通气清醒患者早期床边坐起活动方案的最佳证据，为临床医护人员实施其床边坐起实践提供参考。 方法 基于PIPOST确定循证问题，制订检索策略，计算机检索国内外专业指南网、协会网及数据库内有关ICU机械通气清醒患者早期床边坐起的所有指南、证据总结、最佳实践信息册、推荐实践、系统评价及原始研究。由循证小组对纳入文献进行质量评价、证据提取和总结。结果 最终纳入文献14篇，包括3篇指南、1篇系统评价、1篇证据总结、9篇原始研究，综合为11个维度的证据，分别是组建多学科团队、床边坐起宣教、床边坐起前评估、床边坐起开始时间、床边坐起前准备工作、床边坐起方式、床边坐起频次、呼吸机模式选择、患者安置、床边坐起监测管理、床边坐起终止标准，共25条证据。结论 ICU机械通气清醒患者早期床边坐起具有重要实践意义，医护人员需要根据患者早期床边坐起的异质性进行科学管理，强化早期床边坐起的质量控制，确保患者安全。

Objective To evaluate the relevant evidence of bedside sitting in ICU awake patients with mechanical ventilation，so as to provide a reference for clinical medical staff to implement their practice of bedside sitting. Methods Based on PIPOST，evidence-based questions were identified，search strategies were developed，and all guidelines，evidence summaries，best practice information books，recommended practices，systematic reviews and original studies on bedside sitting of mechanically ventilated awake patients in ICU were searched by computer in professional guide networks，association networks and databases at home and abroad. The quality evaluation，evidence extraction and evidence summary of the included literatures were carried out by the evidence-based team. Results 14 literatures were included，including three guidelines，a systematic review，an evidence summary and nine original studies. 25 pieces of evidence were summarized into 11 dimensions，including the establishment of multidisciplinary team，bedside sitting education，bedside sitting assessment，bedside sitting start time，bedside sitting preparation，bedside sitting mode，bedside sitting frequency，ventilator mode selection，patient placement，bedside sitting monitoring management，and termination standards. Conclusion Bedside sitting in awake patients with mechanical ventilation in ICU has important practical significance. Medical staff should scientifically manage bedside sitting according to the heterogeneity of bedside sitting，strengthen the quality control of bedside sitting，and ensure the safety of patients.